Tennessee’s neutral-site match against Syracuse at Atlanta’s Mercedes-Benz Stadium is one of the highly anticipated games for college football’s opening weekend, and oddsmakers are already making waves with their early predictions.

Tennessee comes into the game as a 12.5-point favorite over Syracuse, according to FanDuel Sportsbook. This sizable spread raises eyebrows, especially considering both teams will have new starting quarterbacks, and a lot of uncertainty surrounds both programs.

The Vols are adjusting to life without Nico Iamaleava after his unexpected departure, and transfer Joey Aguilar is expected to take over as the starting quarterback. He inherits an offense that’s trying to maintain Josh Heupel’s fast-paced style, but it lacks the same continuity and explosiveness that previous Tennessee teams had.

Syracuse is also facing its own set of changes. After spring camp, the Orange brought in Notre Dame transfer Steve Angeli, who will compete with Rickie Collins for the starting quarterback role. With new head coach Fran Brown aiming to bring a tougher, more SEC-like mentality to the team, Syracuse might be more prepared for this neutral-site game than the spread suggests.

CBS Sports’ Brad Crawford believes the game could end up being more closely contested than early expectations show, and he may have a point. The nearly two-touchdown spread seems generous for a Tennessee team that’s transitioning with a new quarterback and adjusting its offensive identity.

With both teams undergoing significant changes and several questions still unanswered by kickoff, this season opener could be more unpredictable than the betting lines imply.